While Peripheral Nervous System conditions account for the majority of Ig use in neurology, there is a small, but growing, use of Ig for Central Nervous System (CNS) conditions.  In order to address this need a working group made up of neurologists, CNS specialists and transfusion medicine physicians was established to develop treatment recommendation for IVIg use for CNS conditions in BC. These recommendations, along with additional resources, are intended to support clinicians in diagnosing and managing these conditions. The program will officially launch on February 1, 2023 with the intention to provide access to neurology expertise and to ensure appropriate Ig utilization.

Sincere thanks to the CNS Ig Use Working Group members for their time and contribution in developing these valuable resources: Dr. Robert Carruthers, Dr. Helen Cross,  Dr. Jennifer Percy, Dr. Dewi Schrader, Dr. Anthony Traboulsee, and Dr. Chris Uy.

CNS Condition List


Neurologist Resources:

Conditionally Approved
Neuromyelitis Optica Spectrum Disorders (NMOSD)

Dec 2022

MOG Antibody Disease (MOGAD) Dec 2022
Acute Disseminated encephalomyelitis (ADEM) Refer to NMOSD or MOGAD
Transverse Myelitis Refer to NMOSD or MOGAD
Optic Neuritis Refer to NMOSD or MOGAD
Stiff Person Spectrum Disorder  Dec 2022
Progressive Encephalitis with Rigidity and Myoclonus (PERM) Refer to Stiff Person Spectrum Disorder
Antibody Mediated Autoimmune Encephalitis (AMAE) Dec 2022
Antibody Negative Autoimmune Encephalitis (ANAE) Refer to  Antibody Mediated Autoimmune Encephalitis (AMAE)
CNS Complications of Systemic Vasculitis Under development
Automimmune Epilepsy Dec 2022
Febrile Infection-Related Epilepsy Syndrome (FIRES) / New-Onset Refractory Status Epilepticus (NORSE) Dec 2022
Super Refractory Status Epilepticus

Dec 2022

Severe Disabling Drug Resistant Non-Surgical Epilepsy Dec 2022
Rasmussen Encephalitis Dec 2022
Childhood Epileptic Encephalopathy Dec 2022
Landau Kleffner Syndrome Refer to Childhood Epileptic Encephalopathy
Electrical Status Epilepticus in Sleep Syndrome (ESES) Refer to Childhood Epileptic Encephalopathy
PANDAS Under development
Opsoclonus Myoclonus Under development
Susac Syndrome Dec 2022
Only in Exceptional Circumstances 
Paraneoplastic Cerebellar Degeneration Dec 2022
Lennox Gastaut Dec 2022
Atypical Rolandic Epilepsy Refer to Lennox Gastaut
West Syndrome Refer to Lennox Gastaut
Multiple Sclerosis Dec 2022
 Not Indicated
Lupus Cerebritis Dec 2022
Myalgic Encephalitis or Chronic Fatigue Syndrome Dec 2022